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KMID : 0438219730100030925
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Korea University Medical Journal
1973 Volume.10 No. 3 p.925 ~ p.939
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The Histopathological Study on the Influence of Various Stimuli at the Nasal Septum upon the Digestive Organs in Rabbits
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Abstract
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Stimuli to the nasal mucous membrane may result not only in local reactions such as sneezing and rhinorrhea but in some characteristic changes on the other organs including distant ones. These can be asthma, spasm of vocal cords, palpitation, arhythmia, gastric clamps, indigestion, dysmenorrhea, and abortion, etc. and are generally known as Reilly´s phenomenon.
Author investigated mostly the histopathological changes of the digestive tract after giving several types of different stimuli on the antero-inferior portion of the left nasal septum of normal healthy adult house rabbits.
The stimuli given were as follows:
1. Control group : 0.5cc of 0.85% saline solution was injected to the submucosa of the left nasal septum.
2. Procaine group : 0.5cc of 1.0% procain hydrochloride solution was given to the same injection site as above.
3. Pilocarpine group : 0.5cc of 0.1% pilocarpine hydrochloride solution was given as above.
4. Electrocautery group : with help of hyfrecator the antero-inferior portion of the left nasal septum was electrocauterized for 3 seconds.
Experimental animals were sacrificed immediately or 30 minutes, 1 hour and 2 hours later respectively after stimulations, then specimens for microscopic examination were obtained from buccal mucosa, tongue, esophagus, stomach, liver, small and large intestines, and stained with H-E solutions.
Changes of right and left half of the same organ were also observed when possible. The results obtained were:
1. The severity of the histopathological changes of digestive tract observed differs according to the stimuli given but the character of tissue changes is same in all groups regardless of the kind of stimuli.
2. Among the stimuli carried, the most striking changes were observed in pilocarpine and electrocautery groups and the least changes in the control group at which saline solution was used for injection.
3. Among the histopathological changes, the most remarkable and constant finding was capillary congestion while the edema of peri-capillary tissue came next. Swelling of the connective tissue fibers and cloudy swelling of the lining epithelial cells were occasional and late findings.
4. Among the organs observed, liver was the one that showed the most conspicious changes including marked congestion of central veins and hepatic sinuses.
5. In comparison of right and left side of the organs as far as the histopathological changes are concerned, it seemed to be no marked differences between two sides except in few organs.
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